GLP-2 and leptin are associated with hyperinsulinemia in non-obese female migraineurs.

Hyperinsulinemia is a condition in which there are excess levels of insulin circulating in the blood relative to the level of glucose. While it is often mistaken for diabetes or hyperglycaemia, hyperinsulinemia can result from a variety of metabolic diseases and conditions. [wikipedia]

Typically, hyperinsulinemia is associated with obesity.

Interesting here that 1) it’s happening in non-obese migraineurs 2) there’s A LOT of food stuff around migraine – eating the wrong food, not eating at the right time, not eating regularly enough, weight gain associated with migraines, etc.