GLP-2 and leptin are associated with hyperinsulinemia in non-obese female migraineurs.
Hyperinsulinemia is a condition in which there are excess levels of insulin circulating in the blood relative to the level of glucose. While it is often mistaken for diabetes or hyperglycaemia, hyperinsulinemia can result from a variety of metabolic diseases and conditions. [wikipedia]
Typically, hyperinsulinemia is associated with obesity.
Interesting here that 1) it’s happening in non-obese migraineurs 2) there’s A LOT of food stuff around migraine – eating the wrong food, not eating at the right time, not eating regularly enough, weight gain associated with migraines, etc.
Fake acupuncture works about as well as real acupuncture for migraine which works as well as or better than standard migraine treatments.
Which is to say, we are utterly shit at treating migraine and at least acupuncture won’t make you gain weight/lose weight/lose the ability to speak/make you suicidal/destroy your digestive system/make you stupid/etc.
Also, if you would like to come and give me fake acupuncture, I will cook you dinner.
Amitrityline and Flunarizine, commonly used for migraine, cause weight gain, likely by inducing leptin resistance.
July 20, 2016
For headache specialists, reducing the disorder to a specific mechanism in the brain doesn’t just relieve the symptoms of migraine [referring to development of Imitrex]; it also targets the stigma associated with it by shifting responsibility for the pain away from a weak or neurotic personality toward a body over which the patient has no control. In this, headache specialists are demonstrating a phenomenon known to cognitive psychologists, namely, that attributing low causal responsibility to stigmatized behaviors reduces blame and produces more positive feelings.
Joanna Kempner in Not Tonight